Stealth-Adapted Viruses and Alternative Cellular Energy

Category: Basic Science/Molecular Biology
W John Martin
Center for Complex Infectious Diseases, Rosemead, CA
Keyword: Simian cytomegalovirus, Cellular energy, Polio vaccine

Stealth-adaptation is a proposed mechanism that allows cell damaging (cytopathic) viruses to evade immune elimination through the deletion of genes coding the major antigens targeted by the cellular immune system. A prototype stealth-adapted virus cultured from a patient with chronic fatigue syndrome was readily transmissible to cats in which it induced an acute encephalopathy without localizing neurological signs. Vacuolating cellular damage was observed in many tissues of the animals, including the brain, in the absence of an accompanying inflammatory response. Comparable cellular changes were inducible in cultures of blood and cerebrospinal fluids of patients with a wide range of neurological and psychiatric illnesses. The virus cultured from the chronic fatigue syndrome patient was cloned and partially sequenced. It comprises a fragmented, genetically unstable genome. It has viral sequences that can be aligned to various regions of the genome of human cytomegalovirus. Regions corresponding to genes coding the three major antigenic targets for anti-CMV cytotoxic T cells were absent or mutated. Where the comparison can be made, the sequences match much more closely to those of African green monkey simian cytomegalovirus (SCMV), indicating a presumptive origin from SCMV. FDA has reported that 3 of 8 licensed batches of polio vaccines released in the mid 1970's contained residual DNA of SCMV. Although the FDA was unable to culture live virus from these vaccines, the possibility exists that stealth-adapted SCMV has entered into humans from contaminated polio virus vaccines. An alternative (non-mitochondria) cellular energy (ACE) pathway is of importance in recovery from stealth-adapted viruses and can cause otherwise positive virus cultures to appear negative. Cellular energy is derived from mineral containing ACE particles that can accumulate in infrequently refed stealth virus cultures. The ACE pathway can also participate in the recovery from conventional infections as well as other illnesses. Enhancing this pathway can potentially provide a powerful adjunct to vaccination programs.

Alternative Cellular Energy Based Therapy of Childhood Diarrhea
Category: Clinical Tropical Medicine
Rafael R. Izaguirre 1 , Miguel R. Guzman 1 , Rafael C. Fuentes 1 , Carlos E. Mena 1 , Emillio Penate 1 , W John Martin 2
1 Benjamin Bloom National Children's Hospital, San Salvador, El Salvador, 2 Center for Complex Infectious Diseases, Rosemead, CA, United States
Presentation Number: 703
Keyword: enercel, energy, homeopathy

Enercel is a licensed water product that is able to convert physical energies into a biological energy that can be utilized by cells to help maintain normal function. It is generated by successively diluting a mixed solution of various minerals and diluted products from the Homeopathic Pharmacopoeia into water containing 4.0% v/v alcohol. Enercel is bottled using Good Manufacturing Practice (GMP) procedures and quality controlled by Vijosa Laboratory, at San Salvador , El Salvador . In the present study, Enercel was evaluated as an adjunct to the routine care of children under 5 years of age presenting with acute diarrhea. An intramuscular injection of 3 ml of Enercel was provided to a randomized group of children (n = 58) upon hospital admission and again 12 hours later. The children were discharged at 24 hours and reexamined 48 hours later. Compared to the initially well matched randomized control group (n = 53), at 48 hours post hospital discharge the Enercel treated group had fewer children with persisting increased peristalsis (p<0.001), dehydration (p=0.0224), fever (p=0.0126) and continued multiple bowel movements (p=0.0035). Benefit occurred in both rotavirus antigen positive and rotavirus negative children with acute diarrhea. Enercel represents a class of broadly acting non-toxic therapies that can seemingly enhance the body's capacity to regain normal cellular function through a recently defined alternative cellular energy (ACE) pathway. Enercel and related products have potential application in the prevention and therapy of many of the major illnesses in both developing and developed countries.