The ultimate therapeutic approach is aimed at suppressing viral expression and the further spread of viral infection. Well conducted clinical trials, supported by appropriate laboratory studies, are urgently needed. In the interim, patients are well advised to adjust sensory inputs to avoid aggravating stimuli and to encourage any behaviors that ameliorate symptom severity.

Next in line in terms of currently available treatments are efforts to augment general cellular metabolic fitness using nutritional supplements. Theoretically, one could be "feeding the virus" and/or destabilizing the virus-host relationship with any type of metabolic intervention.

Some clinicians have noted at least temporary clinical improvement in patients receiving intravenous and/or oral anti-viral agents such as ganciclovir (Protocols available on request). Other clinicians have had success with low doses of various neuro-modulating agents. Specific symptoms such as pain, insomnia depression, anxiety and fatigue can be addressed pharmacologically. The patient should be encouraged to maximize the potential placebo effects of prescribed medications, while at the same time remain objective when comparing therapies. The prescribing physician needs to be sensitive to potential adverse effects, especially given the multiple chemical sensitivity exhibited by this patient population. Non-neurological illness, especially those that can indirectly affect neuronal function, for example leaky bowel with impaired liver detoxification, hypo- or hyperthyroidism, adrenal insufficiency, hypo- and hypertension, etc., need to be addressed on an individual basis.